David N Brindley Selected Research

ONO-8430506

9/2015	Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression.
8/2015	Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer.
3/2015	Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment.
6/2014	Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice.

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David N Brindley Research Topics

Disease

38	Neoplasms (Cancer) 02/2022 - 08/2004
22	Neoplasm Metastasis (Metastasis) 02/2022 - 08/2004
21	Breast Neoplasms (Breast Cancer) 02/2022 - 03/2007
6	Inflammation (Inflammations) 01/2021 - 08/2004
5	Insulin Resistance 02/2015 - 06/2008
4	Infections 09/2021 - 10/2003
4	Obesity 04/2015 - 07/2008
3	Radiation Fibrosis Syndrome (Radiation Fibrosis) 08/2020 - 01/2020
3	Lipodystrophy 12/2017 - 02/2007
3	Papillary Thyroid Cancer 12/2016 - 08/2015
3	Pathologic Processes 11/2015 - 05/2009
2	Fibrosis (Cirrhosis) 04/2020 - 03/2018
2	Idiopathic Pulmonary Fibrosis 02/2020 - 01/2020
2	Thyroid Neoplasms (Thyroid Cancer) 08/2015 - 11/2014
2	Atherosclerosis 04/2015 - 06/2008
2	Melanoma (Melanoma, Malignant) 01/2011 - 09/2009
2	Wounds and Injuries (Trauma) 04/2006 - 08/2004
1	Lung Diseases (Lung Disease) 09/2021
1	Pregnancy Complications 01/2021
1	Pre-Eclampsia (Preeclampsia) 01/2021
1	Gestational Diabetes (Gestational Diabetes Mellitus) 01/2021
1	Rhabdomyolysis 01/2021
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 01/2021
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019
1	Ovarian Neoplasms (Ovarian Cancer) 01/2019
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2017
1	Lymphatic Metastasis 12/2016

Drug/Important Bio-Agent (IBA)

15	LipidsIBA 09/2021 - 08/2004
10	Proteins (Proteins, Gene)FDA Link 02/2022 - 08/2004
6	Phosphates (Orthophosphate)IBA 01/2020 - 08/2004
6	CytokinesIBA 01/2020 - 08/2015
5	lysophosphatidic acidIBA 12/2020 - 11/2007
5	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 08/2020 - 11/2007
4	Messenger RNA (mRNA)IBA 02/2022 - 07/2008
4	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2021 - 01/2014
4	EnzymesIBA 01/2021 - 02/2007
4	ChemokinesIBA 01/2020 - 08/2015
4	ONO-8430506IBA 09/2015 - 06/2014
4	Fatty Acids (Saturated Fatty Acids)IBA 02/2015 - 03/2007
3	Dexamethasone (Maxidex)FDA LinkGeneric 04/2020 - 01/2019
3	lipid phosphate phosphataseIBA 02/2020 - 03/2018
3	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2020 - 08/2004
3	AntioxidantsIBA 02/2016 - 07/2014
3	Insulin (Novolin)FDA Link 02/2015 - 06/2008
3	lipineIBA 09/2012 - 02/2007
3	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 01/2011 - 08/2004
2	Viral DNAIBA 02/2022 - 03/2019
2	DNA (Deoxyribonucleic Acid)IBA 02/2022 - 09/2021
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 09/2021 - 12/2016
2	GLPG1690IBA 02/2020 - 01/2020
2	Lysophosphatidic Acid ReceptorsIBA 01/2020 - 11/2007
2	CollagenIBA 03/2019 - 01/2019
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 08/2015
2	Docetaxel (Taxotere)FDA Link 01/2017 - 01/2014
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2017 - 09/2015
2	Glucose (Dextrose)FDA LinkGeneric 02/2015 - 06/2008
2	Nonesterified Fatty Acids (NEFA)IBA 02/2015 - 06/2008
2	Triglycerides (Triacylglycerol)IBA 05/2010 - 12/2008
2	NF-kappa B (NF-kB)IBA 12/2008 - 01/2005
2	Docosahexaenoic AcidsIBA 12/2008 - 03/2007
2	Eicosapentaenoic AcidIBA 12/2008 - 03/2007
1	Glycoproteins (Glycoprotein)IBA 02/2022
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 09/2021
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2021
1	Mitochondrial DNA (mtDNA)IBA 01/2021
1	CeramidesIBA 01/2021
1	Interleukin-9 (Interleukin 9)IBA 01/2020
1	Macrophage Colony-Stimulating FactorIBA 01/2020
1	Caspase 3 (Caspase-3)IBA 01/2020
1	AdiponectinIBA 11/2019
1	SphingolipidsIBA 01/2019
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2019
1	Cyclin D3IBA 01/2019
1	matrigelIBA 01/2019
1	Matrix Metalloproteinases (MMPs)IBA 01/2019
1	Cyclin D1IBA 01/2019
1	Vinca AlkaloidsIBA 01/2017
1	Doxycycline (Periostat)FDA LinkGeneric 01/2017
1	Colchicine FDA LinkGeneric 01/2017
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2017
1	Poly (ADP-Ribose) Polymerase-1IBA 01/2017
1	TetracyclinesIBA 01/2017
1	taxaneIBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2016
1	IodidesIBA 10/2016
1	IodineIBA 10/2016
1	Tamoxifen FDA LinkGeneric 02/2016
1	Oxidoreductases (Dehydrogenase)IBA 02/2016
1	NAD (NADH)IBA 02/2016
1	Estrogen ReceptorsIBA 02/2016
1	Protein Isoforms (Isoforms)IBA 11/2015
1	Complement System Proteins (Complement)IBA 08/2015
1	Becaplermin (PDGF-BB)FDA Link 08/2015

Therapy/Procedure

15	Radiotherapy 09/2021 - 01/2013
14	Drug Therapy (Chemotherapy) 09/2021 - 09/2009
9	Therapeutics 02/2020 - 04/2007
1	Immunotherapy 12/2020
1	Segmental Mastectomy (Lumpectomy) 11/2019
1	Lasers (Laser) 01/2017